Description
MOTS-c is a 16-amino-acid, mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA. It is commonly investigated in laboratory research involving cellular energy regulation, metabolic signalling and the response of cells to physical or metabolic stress.
It is supplied as a lyophilised (freeze-dried) vial for laboratory research and educational use only.
Each batch is produced to
99%+ purity, with third-party sample testing and full Certificate of Analysis support for mass and purity, helping researchers assess the identity, quality and consistency of the materials supplied.
Reported Areas of Research Interest
MOTS-c has been studied primarily in laboratory and animal models for its reported involvement in mitochondrial communication and the regulation of cellular metabolism.
Areas of scientific investigation include:
- Mitochondrial and cellular energy regulation
- Glucose utilisation and metabolic homeostasis
- Insulin-signalling and sensitivity pathways
- Skeletal-muscle metabolism
- AMPK-related cellular signalling
- Cellular responses to metabolic stress
- Nuclear gene expression and stress adaptation
- Exercise, physical-performance and ageing models
Research suggests that MOTS-c can move into the cell nucleus during metabolic stress, where it may influence the expression of genes involved in cellular protection and adaptation. This process has been associated with AMPK-dependent signalling and communication between the mitochondria and the nucleus.
Preclinical studies have also investigated MOTS-c in relation to skeletal-muscle glucose metabolism, insulin resistance, metabolic flexibility and diet-related metabolic changes. Reported outcomes involving body weight, insulin sensitivity or physical performance have largely come from cell-based and animal models and should not be interpreted as established human benefits.
Human research has examined naturally occurring MOTS-c levels and their relationship with exercise and metabolic health. However, evidence involving the administration of synthetic MOTS-c in humans remains extremely limited, and its safety, effectiveness and appropriate clinical application have not been established.
Bacteriostatic water and research accessories are sold separately.
For research purposes only. Not for human or animal consumption, or for clinical, diagnostic or therapeutic use.
Research & documentation
Supplied for laboratory research only. Understand the science, evidence and quality behind this material:
Research use only
All products supplied by Light Peptides are intended strictly for in-vitro laboratory research and development. They are not medicines, dietary supplements, cosmetics or food, and are not for human or veterinary consumption, diagnostic or therapeutic use. Sold only to qualified purchasers aged 18 or over. By ordering, the purchaser confirms they are a professional researcher and accepts sole responsibility for lawful handling, storage and disposal in accordance with applicable regulations. Nothing on this site constitutes medical advice or a claim of any therapeutic effect.
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